Can taking seroquel and pristiq (desvenlafaxine) make you depressed some more?

Depressed Mood. I have not seen depression listed as a side effect of Pristiq. 1% to 10% of people taking seroquel can develop depressive symptoms. Seroquel (quetiapine) plus Pristiq (desvenlafaxine) may ^ risk for dizziness, drowsiness, confusion & problems concentrating.
Not generally. Pristiq (desvenlafaxine) is a newer antidepressant. Although patients do complain more about side effects, which in of themselves may be depressing!