What can cause a fever, and an itchy rash on the palm of your hands?

Infection autoimmmue. Either an infection, mainly viral, or if there is no sign of an infection then an immunologic process could be occurring, such as an allergic reaction, or an autoimmune process. If this persists or recurs then it needs to be evaluated by a board certified allergist.

Related Questions

What would cause the palm of my hands to breakout in an itchy rash?

Contact or drug. The cause is often unknown but contact dermatitis or a drug reaction (called fixed drug eruption) may induce the palm rash. Consider seeing a dermatologist who may order patch skin testing on you. Read more...