Red, raised, rash on arms and legs, allergic raction from Depo-Provera provera (medroxyprogesterone) shot?

Reaction to Depo. Can happen, usually due to the carrier the progestin is in, but could also be the progestin itself. Unfortunately, once you get the shot, you are along for the ride. Allergy treatment is about the best you can do, usually using an anti-histamine. A natural approach is quercitin, a natural antihistamine found in the skin of red apples.