Can chemotherapy make you get a headache?

Zofran (ondansetron)? The more common issue is that the antinausea medicine causes the headache--especially zofran, (ondansetron) kytril, aloxi. So check your meds and ask your nurse or doctor.
Someitmes. There are a long list of side effects from chemotherapy and some patients do have headaches. Some of the medications used to prevent nausea actually can cause migraine headache. Some of the medications used to prevent low blood counts can also cause more generalized aches.