Are there adverse reactions to epi-pens?

Yes. Anyone who uses the epi-pen should be evaluated in the emergency department or by their physician after use to monitor for side effects which include but are not limited to increased heart rate, increased blood pressure, heart palpitations, arrhythmias- abnormal heart rhythms, tremor, and anxiety.
Yes. The greatest danger is injecting Epinephrine into your thumb. This occurs if you hold your thumb over the orange end while holding the blue end against the thigh. The needle comes out of the orange end! older persons with coronary artery narrowing should use Epipen (epinephrine) with caution. Nausea and hyperactivity are brief occasional adverse effects. Epipen (epinephrine) is a very safe & effective medication.