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What is the difference between a mutation and a chromosomal abnormality?

2 doctors weighed in
Dr. Nikolaos Zacharias
Obstetrics & Gynecology - Maternal Fetal Medicine
1 doctor agrees

In brief: Size.

Mutations are strategically placed minute changes in dna that change the message encoded in it to produce abnormal proteins and pathological symptoms.
Chromosomal abnormalities (e.g. Down syndrome), are larger changes in the number of dna packages (chromosomes) each cell carries, so that many organ systems malfunction (brain, heart, bone marrow, etc).

In brief: Size.

Mutations are strategically placed minute changes in dna that change the message encoded in it to produce abnormal proteins and pathological symptoms.
Chromosomal abnormalities (e.g. Down syndrome), are larger changes in the number of dna packages (chromosomes) each cell carries, so that many organ systems malfunction (brain, heart, bone marrow, etc).
Dr. Nikolaos Zacharias
Dr. Nikolaos Zacharias
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