Depends on organ. Affected. Signs and symptoms of wilson's disease include: clumsiness, depression, difficulty speaking, difficulty swallowing, difficulty walking, drooling, easy bruising, fatigue, involuntary shaking, joint pain, loss of appetite, nausea, skin rash, swelling of arms and legs, yellowing of the skin and eyes. Check this site: http://www.Mayoclinic.Com/health/wilsons-dis.
Vague. It is very easy to overlook the subtle mental and movement changes that warn of Wilson's. The elevated liver enzymes, possible Fanconi syndrome revealed on urinalysis, and/or the low-grade hemolysis cause no symptoms. By the time the KF rings are visible in the eye, the disease is advanced. Have a high index of suspicion.