3 doctors weighed in:

How commonly is congenital heart disease genetic?

3 doctors weighed in
Dr. James Ferguson
Pediatrics
2 doctors agree

In brief: Polygenic problem

The information that codes for proper heart formation is shared by many genes on chromosomes.
Genetic studies show linkage, where a person with a form of chd has a 4% chance of having a first degree relative with any form of chd as well as a 4% risk of having a child with a chd. A few rare syndromes have higher genetic risk (dominant = 50%) that sometimes have chd as part of the syndrome.

In brief: Polygenic problem

The information that codes for proper heart formation is shared by many genes on chromosomes.
Genetic studies show linkage, where a person with a form of chd has a 4% chance of having a first degree relative with any form of chd as well as a 4% risk of having a child with a chd. A few rare syndromes have higher genetic risk (dominant = 50%) that sometimes have chd as part of the syndrome.
Dr. James Ferguson
Dr. James Ferguson
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