For a synovial sarcoma are imatinib or everolimusm effective?

These have no. Established role in front line therapy. Are they being offered on a clinical trial? Both are costly, and possibly of theoretic use. Ask for the strength of the data (it will be called a phase ii trial), .

Related Questions

What are the current immuno-therapies for synovial sarcoma? How effective are them?

Experimental. Despite "pop" claim and excitement, immunotherapy has historically been a bust for sarcomas. There 's some new stuff but it'a way early. There is a melanoma-sarcoma group at Sloan Kettering; Dr. D'Angelo may have something. Good luck. Read more...

What are the current targeted gene therapies for synovial sarcoma? How effective are they?

Very early . Nothing is standard. Phone the folks at the National Cancer Institute and see if you can get into a study. Even if it does not help, you have advanced scientific knowledge for the next person. Read more...
Pazopanib. Combination chemotherapy with doxorubicin and ifosfamide is standard and efficacious. We use pazopanib in second line to target VEGFR, FGFR, PDGFR, and other proteins. Also many targeted immunotherapies are in trials: https://clinicaltrials.sylvester.org. Read more...

What does it mean to have synovial sarcoma?

It's a cancer. It usually occurs in the soft tissues near joints. Unlike other soft tissue sarcomas, that are painless, it can be painful. It is treated with surgery and radiation. Use of chemotherapy if the tumor hasn't spread is controversial. If the cancer spreads, it usually goes to the lungs. With proper treatment, chances of survival are quite good. Read more...

Is synovial sarcoma a serious cancer?

Yes. It is not. Common, unlike its name, does not always occur at joints, but is lumped as a "soft part sarcoma" so it can metastasize to lungs, but unlike many sarcomas, it can also travel to lymphnodes. Resection free margins is key. Best wishes & good luck. Read more...
Very. It will invariably kill if it is untreated. If it has spread to the lungs, we presently have no cure. If it has not, with today's therapy (surgery; the value of radiation and/or chemotherapy, depending on the stage of tumor and type of treatment) more than 50% of patients survive 5-years, the majority of these disease-free. Good luck. Read more...

What is the treatment for synovial sarcoma?

It is not. A common dx, unlike its name, does not always occur at joints, but is lumped as a "soft part sarcoma" so it can metastasize to lungs, but unlike many sarcomas, it can also travel to lymph nodes. Resection free margins is key. Even 1 node conveys higher risk of relapse. Statistics don't help. You have a chance! Read more...
Surgery foremost. There are conflicting results on whether radiation and/or any chemotherapy protocol helps at any particular stage. If the tumor has not spread to the lungs, for most patients a 5-year disease-free survival is more likely than not. Unoperated, the disease is lethal. Good luck, and thanks for asking. Read more...

Are there any treatments for synovial sarcoma?

Yes. Treatment of synovial sarcoma is centered on surgical removal of the tumor with a cuff of normal tissue around it (medical term is wide resection). Radiation is given either before or after surgery in many cases. Use of chemotherapy is controversial as it gives a minimal improvement in survival rates at best. Chances of cure are about 60-70% overall, but every case is different. Read more...
Yes. . As per NCCN guidelines, patients should be diagnosed and managed at a multidisciplinary sarcoma center when possible. If tumor is localized, surgery and radiation are recommended with chemotherapy generally reserved for patients for patients with intermediate or high grade tumors larger than 5 cm. Chemotherapy is the mainstay of therapy for patients whose tumors have spread. . Read more...

What is the best treatment for synovial sarcoma?

It is not. A common dx, unlike its name, does not always occur at joints, but is lumped as a "soft part sarcoma" so it can metastasize to lungs, but unlike many sarcomas, it can also travel to lymph nodes. Resection free margins is key. Even 1 node conveys higher risk of relapse. Statistics don't help. You have a chance! Read more...
Still under study. Everyone agrees that surgery is foremost. Whether local radiation and/or adjuvant chemotherapy (and if so what kind) are helpful is still up for grabs, with different studies giving different results for different stages of tumor. Unless the disease has spread to the lungs, the chances of long-term survival are generally better than even. Good luck. Read more...

What should I know about synovial sarcoma and is it a serious cancer?

Can be. A rare form of cancer which usually occurs near to the joints of the arm, neck or leg.Synovial sarcoma occurs most commonly in the young, representing about 8% of all soft tissue sarcomas.Primary treatment for synovial sarcoma is surgery to remove the entire tumor with clear margins when possible. Treatment can involve chemotherapy and radiation. Localized disease has about 70% five year survial. Read more...
Also. It can be serious. In addition to what others have said, these tumors were originally named synovial sarcomas since they occur near joints. However, they actually are not related to the synovium, the lining of the joint and the usually do not connect with the synovium itself. Read more...