5 doctors weighed in:

Loratadine makes me drowsy, should I try cetirizine to see if that doesn't do the same thing?

5 doctors weighed in
Dr. Brian Bezack
Pediatrics - Pulmonology
4 doctors agree

In brief: You can

Loratadine & Cetirizine are both in a class of medications known as non-drowsy long acting anti-histamines.
Although they are in the same class, i still have patients that experience drowsiness (usually more from cetirizine); however, i would try it because everyone responds differently to the same medications. Take it before bed so if drowsy you can go to sleep anyway.

In brief: You can

Loratadine & Cetirizine are both in a class of medications known as non-drowsy long acting anti-histamines.
Although they are in the same class, i still have patients that experience drowsiness (usually more from cetirizine); however, i would try it because everyone responds differently to the same medications. Take it before bed so if drowsy you can go to sleep anyway.
Dr. Brian Bezack
Dr. Brian Bezack
Thank
Dr. Barbara Stark Baxter
Internal Medicine - Allergy & Immunology

In brief: Fexofenadine less

Loratidine has 8% sedation and Cetirizine 13%, so the latter is not actually permitted by the fda to advertise that it is non-sedating.
In practice, i agree, responses vary. Fexofenadine is less sedating (2%) than either, but some patients claim even it sedates. If the antihistamine is for nasal allergies, prescription topical antihistamines are less sedating than oral (but cost more).

In brief: Fexofenadine less

Loratidine has 8% sedation and Cetirizine 13%, so the latter is not actually permitted by the fda to advertise that it is non-sedating.
In practice, i agree, responses vary. Fexofenadine is less sedating (2%) than either, but some patients claim even it sedates. If the antihistamine is for nasal allergies, prescription topical antihistamines are less sedating than oral (but cost more).
Dr. Barbara Stark Baxter
Dr. Barbara Stark Baxter
Thank
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