A swollen throat can be the result of a viral infection and will not respond to amoxicillin.
Furthermore, other bacteria can breakdown the Amoxicillin structure. That is why the best drug empirically to use when you are certain that the infection is bacterial (throat culture), is augmentin (amoxicillin and clavulanate). This antibiotic has clavulinic acid in its make up and will prevent this breakdown of amoxicillin.
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