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What is the difference between weight-based and fixed dose of pegylated interferon?

2 doctors weighed in
Dr. Jack Mutnick
Internal Medicine - Allergy & Immunology

In brief: Interferon

Weight based means that the dose is adjusted for the milligrams per kilogram of the patient whereas a fixed dose simply means everybody, no matter age or weight or gender, gets the exact same dose.

In brief: Interferon

Weight based means that the dose is adjusted for the milligrams per kilogram of the patient whereas a fixed dose simply means everybody, no matter age or weight or gender, gets the exact same dose.
Dr. Jack Mutnick
Dr. Jack Mutnick
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Dr. Brett Kalmowitz
Internal Medicine - Gastroenterology

In brief: Different meds

Peg-intron (alpha 2b) is given as a weight based medication.
Pegasys (peginterferon alfa 2a) (alpha 2a) is given as a fixed dose. The difference has to do with the distribution throughout the tissues and fats of the body. Most docs think the 2 are comparable clinically as long as they are dosed appropriately. If using for treatment of hepatitis c, they should be used in combination with 1 or 2 other meds for best results.

In brief: Different meds

Peg-intron (alpha 2b) is given as a weight based medication.
Pegasys (peginterferon alfa 2a) (alpha 2a) is given as a fixed dose. The difference has to do with the distribution throughout the tissues and fats of the body. Most docs think the 2 are comparable clinically as long as they are dosed appropriately. If using for treatment of hepatitis c, they should be used in combination with 1 or 2 other meds for best results.
Dr. Brett Kalmowitz
Dr. Brett Kalmowitz
Thank
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