11 doctors weighed in:

How does methylphenidate work for ADHD patient? What's the chemical reason in the brain?

11 doctors weighed in
Dr. Divyansu Patel
Psychiatry
5 doctors agree

In brief: Dopamine

It blocks the Dopamine reuptake (prevents the break down of dopamine) in the frontal lobe, which in turn increase Dopamine in the frontal lobe ( executive center of the brain).

In brief: Dopamine

It blocks the Dopamine reuptake (prevents the break down of dopamine) in the frontal lobe, which in turn increase Dopamine in the frontal lobe ( executive center of the brain).
Dr. Divyansu Patel
Dr. Divyansu Patel
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Dr. Carla Enriquez
Pediatrics
4 doctors agree

In brief: Reuptake inhibition

Methylphenidate inhibits the reuptake of norepinephrine & Dopamine in the post-synaptic neuron.
This means it keeps these neurotransmitters around longer at a receiving nerve cell connection (synapse) to get their message across better. Any brain system using norepinephrine or Dopamine can be impacted, not just the ones we want. That's how side effects happen.

In brief: Reuptake inhibition

Methylphenidate inhibits the reuptake of norepinephrine & Dopamine in the post-synaptic neuron.
This means it keeps these neurotransmitters around longer at a receiving nerve cell connection (synapse) to get their message across better. Any brain system using norepinephrine or Dopamine can be impacted, not just the ones we want. That's how side effects happen.
Dr. Carla Enriquez
Dr. Carla Enriquez
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Dr. Jonathan Nehrer
Pediatrics - Psychiatry
3 doctors agree

In brief: Further point

In theory the Dopamine increase also helps the "gating neurons" in the midbrain be more selective and screen out irrelevant signals.

In brief: Further point

In theory the Dopamine increase also helps the "gating neurons" in the midbrain be more selective and screen out irrelevant signals.
Dr. Jonathan Nehrer
Dr. Jonathan Nehrer
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Dr. Alan Ali
Psychiatry
1 doctor agrees

In brief: Ritalin (methylphenidate)

Stimulants work by blocking reuptake of chemicals that enhance attention, hence increasing their amounts in brain.

In brief: Ritalin (methylphenidate)

Stimulants work by blocking reuptake of chemicals that enhance attention, hence increasing their amounts in brain.
Dr. Alan Ali
Dr. Alan Ali
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