3 doctors weighed in:
Can you explain the hemolytic anemia that results from the pk deficiency?
3 doctors weighed in

Dr. Scott Adams
Pediatrics - Hematology & Oncology
2 doctors agree
In brief: Cell membrane damage
Pyruvate a kinase deficiency results in reduced ability of red cells to make atp -the "energy source" of cells.
Atp is also necessary to protect cells from damaging compounds such as free radicals. With decreased energy supply the cell is not able to maintain appropriate concentrations of electrolytes and fluids, becomes distorted or stiff, and then is destroyed in the spleen or liver.

In brief: Cell membrane damage
Pyruvate a kinase deficiency results in reduced ability of red cells to make atp -the "energy source" of cells.
Atp is also necessary to protect cells from damaging compounds such as free radicals. With decreased energy supply the cell is not able to maintain appropriate concentrations of electrolytes and fluids, becomes distorted or stiff, and then is destroyed in the spleen or liver.
Dr. Scott Adams
Dr. Scott Adams
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