Cell membrane damage. Pyruvate a kinase deficiency results in reduced ability of red cells to make ATP -the "energy source" of cells. Atp is also necessary to protect cells from damaging compounds such as free radicals. With decreased energy supply the cell is not able to maintain appropriate concentrations of electrolytes and fluids, becomes distorted or stiff, and then is destroyed in the spleen or liver.
For 57+ female, what are the CBC results to indicate Hemolytic Anemia? Hb 10.6, RBC 3.6, PCV 33.5, Pt 1.2L, MCV 93, MCHC 31.6, Ferritin 36. B12 450.
LDH. All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the results you provided indicate anemia but are not appropriate for a diagnosis of hemolysis. It would have been helpful to have the result of LDH enzyme level.
Blood destruction. Hemolytic anemia is anemia caused by blood cell destruction. Anemia can generally occur due to decreased red blood cell production or to increased red blood cell destruction. Both of these have many underlying causes.
No. The underlying causes of hemolytic anemia can be treated but not prevented.
Possibly. Hemolytic anemia may have numerous causes including toxins, infections, genetic diseases, autoimmune diseases, drugs, certain types of food, etc. So theoretically if you know what the cause is then it can be avoided. Therefore an adequate diagnostic workup by your doctor is necessary.
Clozapine. This is a powerful anti psychotic and is usually used when other type medications do not give the desired results. Monitoring of the blood count is needed to make sure it is not affecting the blood cells mainly the white count. It does not cause hemolytic anemic.
Yes. Yes it can.
No. It can be due to an underlying autoimmune disorder, such as lupus or rheumatoid arthritis. In this case, the underlying autoimmune disorder may be hereditary; but the autoimmune hemolytic anemia is not hereditary. It is simply the manifestation of the underlying disorder. There are also several causes of autoimmune hemolytic anemia that are not inherited.
Blood testing. Specific blood tests to check for blood destruction and reviewing the blood under the microsscope by a trained hematoloist is necessary to establish a diagnosis.
Bloodwork. An examination may reveal an enlarged spleen. Tests include: direct coombs' test hemoglobin in the urine indirect coombs' test red blood cell count and serum hemoglobin reticulocyte count serum bilirubin levels serum haptoglobin.
Stopping dapsone. The best way to treat Dapsone related anemia is by discontinuing dapsone. Dapsone causes hemolytic anemia which is dose-dependent and can be stopped only with discontinuing the drug. Usual practice is to use the lowest possible doses of Dapsone and support with vitamin E and folic acid.
Generally by. .. Stopping the drug first and foremost. Dapsone has two primary effects on the blood, both connected to its oxidant qualities. The first is dose-dependent hemolysis, which is more prominent in g6pd deficiency, and the second is methemoglobinenia, where heme fe is oxidized to the +3 oxidation state. Transfusion support may be necessary as a supportive measure.
Unwise. If you have hemolytic anemia, you probably need to keep all the blood cells you've got! There are many different causes for hemolytic anemia. Check with your local red cross to find out if you qualify.
Usually No. Causes of hemolytic anemia include inherited metabolism or cell membrane disorders and acquired, e.G from antibodies. In either case the average survival of the red cells is shortened, sometimes severely and using such rbcs for transfusion would subject the recipient to more rapid loss of the transfused cells than is desirable, hence we do not use such donor sources.