8 doctors weighed in:

Must both parents have a point mutation in their CF genes in order to create a child with cf?

8 doctors weighed in
Dr. James Ferguson
Pediatrics
4 doctors agree

In brief: Yes, but

It does not have to be the same mutation.
The most common point mutation accounts for about 80% of all CF,with both asymptomatic parents carrying an identical recessive defect. However there are hundreds of variations in the point mutation that could pair up, resulting in a slight difference in the presentation and course of some patients.

In brief: Yes, but

It does not have to be the same mutation.
The most common point mutation accounts for about 80% of all CF,with both asymptomatic parents carrying an identical recessive defect. However there are hundreds of variations in the point mutation that could pair up, resulting in a slight difference in the presentation and course of some patients.
Dr. James Ferguson
Dr. James Ferguson
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Dr. Michael Fisher
Dermatology
2 doctors agree

In brief: Cystic fibrosis

This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations.
The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.

In brief: Cystic fibrosis

This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations.
The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.
Dr. Michael Fisher
Dr. Michael Fisher
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