10 doctors weighed in:
How long does it take for Zoloft (sertraline) to leave your blood stream after you stop taking it?
10 doctors weighed in

Dr. Kevin Nasky
Psychiatry
6 doctors agree
In brief: Days
Based on the half lives of zoloft (sertraline) (22-36 hrs) and its metabolites (62-104 hrs), it will take most people over a week to clear the drug from their system. Other medications can slow or accelerate metabolism of zoloft (sertraline), so keep that in mind as well.

In brief: Days
Based on the half lives of zoloft (sertraline) (22-36 hrs) and its metabolites (62-104 hrs), it will take most people over a week to clear the drug from their system. Other medications can slow or accelerate metabolism of zoloft (sertraline), so keep that in mind as well.
Dr. Kevin Nasky
Dr. Kevin Nasky
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Dr. Gregory Seagraves
Pharmacology
2 doctors agree
In brief: Zoloft (sertraline)
Renal function will also affect the elimination of zoloft (sertraline).

In brief: Zoloft (sertraline)
Renal function will also affect the elimination of zoloft (sertraline).
Dr. Gregory Seagraves
Dr. Gregory Seagraves
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1 doctor agrees
In brief: 3 weeks
This is complicated.
Zoloft (sertraline) has a half-life of about 26 hours, so it takes 4.5 half-lives (5 days) for the level to be less than 5% of its steady state level. But consequences of stopping it, like discontinuation symptoms, may be present even after it has left your blood stream. In my clinical experience, it takes about 3 weeks for those to disappear.

In brief: 3 weeks
This is complicated.
Zoloft (sertraline) has a half-life of about 26 hours, so it takes 4.5 half-lives (5 days) for the level to be less than 5% of its steady state level. But consequences of stopping it, like discontinuation symptoms, may be present even after it has left your blood stream. In my clinical experience, it takes about 3 weeks for those to disappear.
Dr. Robert Berkowitz
Dr. Robert Berkowitz
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