Can ssris and mdma adversely affect each other?

Yes. Ssris increase serotonin levels and can cause life threatening serotonin syndrome. Mdma (ecstacy) is a stimulant that can deplete serotonin levels, damage brain cells, cause stroke, heart attack or death.Taking either one is dangerous.Ecstacy can make you depressed and/or negate the benefits of the ssri don't even think of taking them together.