7 doctors weighed in:
Are there any problems with taking tofranil (imipramine) and sodium valproate at the same time?
7 doctors weighed in

Dr. Alan Ali
Psychiatry
3 doctors agree
In brief: Tofranil (imipramine)
If prescribed & monitored by your doctor, no problem, as long as your moods are stable & no signs of depression.

In brief: Tofranil (imipramine)
If prescribed & monitored by your doctor, no problem, as long as your moods are stable & no signs of depression.
Dr. Alan Ali
Dr. Alan Ali
Thank
Dr. Kevin Passer
Pediatrics - Psychiatry
2 doctors agree
In brief: It Depends
If the combination were used to treat bipolar disorder and the dosage of each adjusted in a judicious and systematic manner with therapeutic blood level monitoring, there may be no real problems.
On the other hand, some studies suggest that folks with bipolar disorder tend to do best overall if they avoid antidepressants like imipramine-aka-tofranil. Of course, that is not always the case.

In brief: It Depends
If the combination were used to treat bipolar disorder and the dosage of each adjusted in a judicious and systematic manner with therapeutic blood level monitoring, there may be no real problems.
On the other hand, some studies suggest that folks with bipolar disorder tend to do best overall if they avoid antidepressants like imipramine-aka-tofranil. Of course, that is not always the case.
Dr. Kevin Passer
Dr. Kevin Passer
Thank
Dr. Thomas Seck
Pediatrics
2 doctors agree
In brief: Possibly
Most people can use this combination without a problem. However, the combination has been shown to increase blood levels of tofranil (imipramine) therefore increasing the chancestofranil (imipramine)'s side effects.
They also have some of the same side effects & that can also increase the risk of side effects. For instance drowsiness/somnolence are side effects of both, so the combination could cause severe drowsiness.

In brief: Possibly
Most people can use this combination without a problem. However, the combination has been shown to increase blood levels of tofranil (imipramine) therefore increasing the chancestofranil (imipramine)'s side effects.
They also have some of the same side effects & that can also increase the risk of side effects. For instance drowsiness/somnolence are side effects of both, so the combination could cause severe drowsiness.
Dr. Thomas Seck
Dr. Thomas Seck
Thank
Dr. Alan Ali
Psychiatry
1 doctor agrees
In brief: Tofranil (imipramine)
Concern with tricyclic antidepressants at therapeutic dose is precipitation of manic episode, as well as side-effects of their own.

In brief: Tofranil (imipramine)
Concern with tricyclic antidepressants at therapeutic dose is precipitation of manic episode, as well as side-effects of their own.
Dr. Alan Ali
Dr. Alan Ali
Thank
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