How/why does sickle cell anemia cause problems when under anaesthetics?

Increased sickling. Multiple factors can result in increased sickling during anesthesia and surgery. Chemical changes in the acidity of the blood, oxygen carrying capacity of the blood, body temperature, etc all increase the risk of sickling. Therefore transfusions are strongly recommended prior to surgery to reduce the total number of red cells with hemoglobin s prior to surgery in an attempt to minimize the risk.
Stress. While under general anesthesia the body is under increased stress both from the anesthesia and the procedure. This increased stress can increase the rate at which cells sickle potentially causing problems.
Sickled red cells. cause vaso-occlusion by clustering and the patients are frequently anemic. They are high risk especially for major procedures.
Sickling. When someone with sickle cell anemia is in crisis their red blood cells are reconfigured into a sickle shape. This sickled shape cannot carry oxygen adequately. This will lead to hypoxemia. .

Related Questions

How does sickle cell anemia cause complications when under anesthetics?

Compromising organs. Sickling of the red blood cells can occur from stress or ketoacidosis (diabetes out of control) and causes of low oxygen in the lungs or blood. This will cause the sickled cells to obstruct the flow of the cells that still are able to carry oxygen to the various organs such as the liver, the brain, heart, muscles and any and all tissue. This compromises function of the organ or tissue. Read more...

How can sickle cell anemia cause osteomyelitis in your bones?

Sickle crisis. The disorder leads to internal clotting during hypoxic states. Any where that happens the organ is damaged. So it is with the circulation in the bones. Read more...
Answered previously. Hi anandk6. I answered this question recently. Can you not find the answer or did i not answer it satisfactorily? Read more...

What is the cause of sickle cell anemia in fetus?

You may be confused. Fetuses do not suffer from sickle cell anemia in utero because they have a different type of hemoglobin (fetal) that is unaffected even in individuals destined to have sickle cell disease later in life. Affected fetuses come from affected or carrier parents and sickle cell disease is a genetic condition without cure at present. See a genetic counselor to discuss these issues in detail. Read more...
Defective genes. The chromosomes contain genes which have the instruction on how the work of the body is done. In SS disease, each parent has given the fetus a defective gene, so defective blood cells would be made after baby is born & becomes an air breather. Before then its red cells are made using other instructions. The parents are unaffected because each has one normal gene that can make good blood cells. Read more...

What cause the symptoms of sickle cell anemia?

Symptoms of SS. The altered shape of the red blood cells causes them to stack up together and clog blood vessels, depriving the tissues of adequate blood supply and oxygen. The tissues then die (infarct) and this causes pain. The red cells also rupture or are eaten by the spleen and cause anemia. The spleen itself will gradually infarct, leaving the patient susceptible to infections. Read more...

Please tell me the cause of sickle cell anemia?

Stiffened hemoglobin. There is a genetic change that causes an abnormal hemoglobin. This abnormal hemoglobin becomes stiff in certain circumstances, causing the red blood cell to sickle. This causes many symptoms, including anemia, pain, and many other symptoms. Read more...
Gene defect. Years ago a mutation in a gene (set of instructions) used to form hemoglobin appeared. A single gene of a pair conferred some resistance to malaria, a germ that invades red cells. With a normal gene paired with the defect, they were able to live normally. If 2 defective genes appear in a person, their red cells are stiff & breakdown quickly (anemia) & are unable to get easily through capillaries. Read more...

Why do I have problems when I swim in extreme hot/cold temperatures with sickle cell anemia?

Sickle cell anemia. Extremes of temperature and physical exertion tasks both the circulation of blood and the individual hemoglobin molecule. So when you are exercising in the heat or cold you are demanding more of the sickled red blood cell as well as your heart to deliver oxygen to your muscles and this is why it is problematic. Read more...
Blood flow changes. Swimming can cool the skin, even when it is warm outside. This can cause decreased blood flow, which has been shown to affect the sickling of sickle cells. If you continue to swim, it would be good to dry off quickly and put on a shirt quickly. This may help. Read more...