5 doctors weighed in:

How/why does sickle cell anemia cause problems when under anaesthetics?

5 doctors weighed in
Dr. Scott Adams
Pediatrics - Hematology & Oncology
3 doctors agree

In brief: Increased sickling

Multiple factors can result in increased sickling during anesthesia and surgery.
Chemical changes in the acidity of the blood, oxygen carrying capacity of the blood, body temperature, etc all increase the risk of sickling. Therefore transfusions are strongly recommended prior to surgery to reduce the total number of red cells with hemoglobin s prior to surgery in an attempt to minimize the risk.

In brief: Increased sickling

Multiple factors can result in increased sickling during anesthesia and surgery.
Chemical changes in the acidity of the blood, oxygen carrying capacity of the blood, body temperature, etc all increase the risk of sickling. Therefore transfusions are strongly recommended prior to surgery to reduce the total number of red cells with hemoglobin s prior to surgery in an attempt to minimize the risk.
Dr. Scott Adams
Dr. Scott Adams
Thank
Dr. Herbert Duvivier
Internal Medicine - Hematology & Oncology
2 doctors agree

In brief: Stress.

While under general anesthesia the body is under increased stress both from the anesthesia and the procedure.
This increased stress can increase the rate at which cells sickle potentially causing problems.

In brief: Stress.

While under general anesthesia the body is under increased stress both from the anesthesia and the procedure.
This increased stress can increase the rate at which cells sickle potentially causing problems.
Dr. Herbert Duvivier
Dr. Herbert Duvivier
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Dr. William Jenkins
Anesthesiology

In brief: Sickled red cells

cause vaso-occlusion by clustering and the patients are frequently anemic.
They are high risk especially for major procedures.

In brief: Sickled red cells

cause vaso-occlusion by clustering and the patients are frequently anemic.
They are high risk especially for major procedures.
Dr. William Jenkins
Dr. William Jenkins
Thank
Dr. Marc Abramson
Anesthesiology

In brief: Sickling

When someone with sickle cell anemia is in crisis their red blood cells are reconfigured into a sickle shape.
This sickled shape cannot carry oxygen adequately. This will lead to hypoxemia.

In brief: Sickling

When someone with sickle cell anemia is in crisis their red blood cells are reconfigured into a sickle shape.
This sickled shape cannot carry oxygen adequately. This will lead to hypoxemia.
Dr. Marc Abramson
Dr. Marc Abramson
Thank
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