What are the effects of nicotine and carbon monoxide on the heart and blood vessels?

Multiple effects. Nicotine increases blood pressure by promoting the constriction of blood vessels, and elevating the heart rate. These effects occur through many mechanisms, including activation of the sympathetic nervous system, adrenal hormone release, and the release of many neurotransmitters. Carbon monoxide is not known to have a direct effect on the heart or vessels, but impairs blood oxygen delivery.