Is it safe to eat or drink before esophageal manometry?

Best not to. Since the study usually is testing during a fasting state, you should not have any solids for at least 6 hours and liquids for 3.
Esophageal Manometry. Why drink before the test. Best to not complicate the test. If you were instructed not to eat or drink before the test, best to comply. The test will be more accurate in determining the source of your difficulty swallowing. Take a break.