How much diphenhydramine do people take to trip?

Trip ?? This is the main component of most over the counter sleep products.Probably 1/20 gan get the opposite reaction but it is not a drug to "trip" on.If you want to go to sleep, fine.If you take a real excess you can have a seizure and die after you suck your own vomit down your windpipe.
Toxicity. Every human body reacts to a drug differently. In some children, even one dose of Benadryl (diphenhydramine) will make them very hyper (known as a paradoxical reaction). First and foremost, you should always follow the labeled instructions on all otc medications. If still unsure, speak to your physician.