7 doctors weighed in:

I know prednisone lowers your immune system, so can I take Benadryl (diphenhydramine) instead?

7 doctors weighed in
Dr. Li-Min Hwang
Obstetrics & Gynecology
3 doctors agree

In brief: Yes, in occasions

You've got an excellent point.
For example, in treating sinusitis caused by allergic nasal congestion, Benadryl (diphenhydramine) treatment has much less side effects than prednesone.

In brief: Yes, in occasions

You've got an excellent point.
For example, in treating sinusitis caused by allergic nasal congestion, Benadryl (diphenhydramine) treatment has much less side effects than prednesone.
Dr. Li-Min Hwang
Dr. Li-Min Hwang
Thank
Dr. John Overholt
Internal Medicine - Allergy & Immunology
2 doctors agree

In brief: Sure

Prednisone is generally reserved for severe allergy symptoms or asthma attacks.
For nasal allergies, instead of Benadryl (diphenhydramine) i'd recommend a longer acting, less sedating antihistamine like Cetirizine or fexofenadine. For asthma, antihistamines won't help.

In brief: Sure

Prednisone is generally reserved for severe allergy symptoms or asthma attacks.
For nasal allergies, instead of Benadryl (diphenhydramine) i'd recommend a longer acting, less sedating antihistamine like Cetirizine or fexofenadine. For asthma, antihistamines won't help.
Dr. John Overholt
Dr. John Overholt
Thank
Dr. James Ferguson
Pediatrics
1 doctor agrees

In brief: Short course OK

Your body makes a stress hormone very similar to Prednisone every day.
A short course (5-7days) is often used to assist your own stress hormone response to get things back in order quickly & avoid prolonged symptoms. Prolonged use can suppress the immune system & should be avoided. Antihistamines can be beneficial if the issue is histamine based but will replicate all the benefits of the steroid.

In brief: Short course OK

Your body makes a stress hormone very similar to Prednisone every day.
A short course (5-7days) is often used to assist your own stress hormone response to get things back in order quickly & avoid prolonged symptoms. Prolonged use can suppress the immune system & should be avoided. Antihistamines can be beneficial if the issue is histamine based but will replicate all the benefits of the steroid.
Dr. James Ferguson
Dr. James Ferguson
Thank
Dr. J. Lawrence Dohan
Dermatology

In brief: Wrong question

Why taking prednisone? Dose and schedule? Duration? Benadryl (diphenhydramine) helps no skin conditions except histamine reactions, mostly hives.
And for that there are much better antihistamines. So they are used in different circumstances. Benadryl (diphenhydramine) is a sleeping pill. Take only at bedtime. You need to indicate the reason for prednisone before any further discussion.

In brief: Wrong question

Why taking prednisone? Dose and schedule? Duration? Benadryl (diphenhydramine) helps no skin conditions except histamine reactions, mostly hives.
And for that there are much better antihistamines. So they are used in different circumstances. Benadryl (diphenhydramine) is a sleeping pill. Take only at bedtime. You need to indicate the reason for prednisone before any further discussion.
Dr. J. Lawrence Dohan
Dr. J. Lawrence Dohan
Thank
Get help from a real doctor now
Dr. Shontae Buffington
Board Certified, Pediatrics
13 years in practice
838K people helped
Continue
108,000 doctors available
Read more answers from doctors