3 doctors weighed in:
Is it safe to take zyrtec and Benadryl (diphenhydramine) at the same time?
3 doctors weighed in

Dr. Nguyen Nguyen
Pediatrics
1 doctor agrees
In brief: No
Both zyrtec and Benadryl (diphenhydramine) belong to the same class of medicines called antihistamines.
Taking both at the same time would be taking a double dose of medicine. Zyrtec is taken once every 12 hours, whereas Benadryl (diphenhydramine) is taken every 4 to 6 hours.

In brief: No
Both zyrtec and Benadryl (diphenhydramine) belong to the same class of medicines called antihistamines.
Taking both at the same time would be taking a double dose of medicine. Zyrtec is taken once every 12 hours, whereas Benadryl (diphenhydramine) is taken every 4 to 6 hours.
Dr. Nguyen Nguyen
Dr. Nguyen Nguyen
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Dr. Randolph Thomas
Pediatrics
In brief: Sedation risk
Both zyrtec and Benadryl (diphenhydramine) are sedating antihistamines.
They should not be taken together unless under the direction of your physician. Occasionally both will be prescribed for a severe case of hives or a severe allergic reaction but they are not usually taken together. The combination could result in over sedation, dizziness, incoordination, dry mucous membranes as well as more serious reactions.

In brief: Sedation risk
Both zyrtec and Benadryl (diphenhydramine) are sedating antihistamines.
They should not be taken together unless under the direction of your physician. Occasionally both will be prescribed for a severe case of hives or a severe allergic reaction but they are not usually taken together. The combination could result in over sedation, dizziness, incoordination, dry mucous membranes as well as more serious reactions.
Dr. Randolph Thomas
Dr. Randolph Thomas
Thank
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