Is it safe to take both zyrtec and benadryl (diphenhydramine)?

Not a good choice. Benadryl (diphenhydramine) is a short acting antihistamine. Zyrtec is a long acting antihistamine. You may overdose if taking both at the same time or taking both in the same day. Consider a better allergy medication if zyrtec is not working well or if you have been taking Benadryl (diphenhydramine) longer than 5 days.

Related Questions

Terrible hives&hot flashes. Rx'd 10mg zyrtec daily&often take benadryl (diphenhydramine) at bedtime. Safe 2gether? What about 20mg zyrtec w benadryl (diphenhydramine)? What else wrks 4 hives

Avoid combination. Both Zyrtec & Benadryl (diphenhydramine) are antihistamines and as such, should not be taken together in same 24hr period due to potential interactions (,569-286). Maximum dose of Zyrtec is 10mg daily so best to avoid exceeding that amount. Check out, & for more info re chronic urticaria (hives). Read more...