What is the difference between high tolerance wrt alcohol and immunity to effects of alcohol?

Semantics? "high tolerance" meaning can drink a lot and not appear intoxicated? (not necessarily a good thing) usually implies chronic use or use of meds that affect metabolism of alcohol. "immunity to effects" meaning no tissue or organ damage to liver, stomach, heart, pancreas, brain, nervous system, etc.? Means relatively protected by genes, luck, diet, or just moderate intake (or less).