Not likely to be ... Either one. Although almost any medicine can cause almost any side effect, bulging veins and feet and ankle swelling wouldn't be likely to be due to taking an snri. Estrogen could conceivably contribute to swelling and visible veins but, as dr. Isobe said, neither is likely to be the cause. Bulging veins and swelling generally means that you have an underlying vein problem that should be treated.
Unlikely. The risk factors for development of prominent bulging veins are heredity, pregnancy, prolonged standing/sitting, age, obesity. The subsequent swelling is a result of venous hypertension due to venous valvular incompetence. Seek help by going to www.Phlebology.Org, and search for a qualified phlebologist in your zip code area to help you.