Methotrexate. The side effects of Methotrexate include liver dysfunction, increased risk of infection, blood count abnormalities, fatigue on the day of treatment and gastrointestinal distress.
See details. What do you mean by sick? If you mean GI problems such as nausea and vomiting, it may last a few days. I would suggest that the Methotrexate be given by injection subcutaneously instead of by mouth. It is easy to do and will avoid GI issues. It may also be more effective this way.