How well does methotrexate work on psoriasis?

Psoriasis . Methotrexate is a terrific therapy for severe psoriasis. It works well, is very inexpensive and is relatively safe when its effects are carefully monitored.

Related Questions

Humira and Methotrexate are not working for my psoriasis. I asked the doctor about Stelara (ustekinumab).  Dr. Hasn't seen good results w/other patients on Stelera so doesn't use it. What would you recommend?

Possibly. It is not uncommon to make treatment decisions based on personal experiences. I am not a dermatologist and i don't have experience with stelera. 3 other tnf's may provide good results. They are enbrel, simponi, (golimumab) and remicade. Read more...
Stelara (ustekinumab) Stelara (ustekinumab) is a terrific drug for severe psoriasis and often works when Methotrexate and Humira are ineffective. The beauty of this therapy is that you will need only one injection every 3 months. Read more...
Try others. There are other good biologics, enbrel(very safe), and remicade(very effective) you may try. Not all biologics are equally effective for individuals. Sometimes, docs would try combinations. Read more...
STELERA/HUMIRA/METHT. Well if you have no improvement with Humira (adalimumab) and methtrexate, than there is no harm in trying stelera.Discuss with your doctor that it is not working, so what is the harm in trying if stelera will work for you otherwise you can get a second opinion from another dermatologist. Read more...

Can methotrexate treat psoriasis?

Yes. Yes, it is one of many treatments available to patients with psoriasis. A dermatologist should be able to tell if it is appropriate for any particular patient. It has been used for decades, so we have a lot of experience with this drug. Read more...
Yes. Agree, but.... Methotrexate can be very effective. However, the first studies raising the specter of liver disease came from psoriasis patients on daily low dose oral mtx!. The first pass effect is dangerous for the liver. Mtx cannot be adjudicated aqs an oral drug. Absorption is variable (40-90%), causes GI upset, and hits the liver first. I only use subcutaneous mtx once weekly. This is the safest! Read more...

What are the side effects of methotrexate for psoriasis worth taking the risk?

Worth the risk. For more severe psoriasis, Methotrexate is definitely worth the risk and really has fairly low risk. Side effects include GI irritation, hair loss, reduced blood counts and liver inflammation. All of these are uncommon. Read more...

I am on methotrexate for severe psoriasis. Can I come off it as I have read of serious side effects. Thanks?

Yes, but. The risk of methotrexate toxicity is fairly low and your psoriasis will flare if you discontinue it. Before doing anything you should discuss this with your dermatologist. . Read more...

My Dr. Wants me back on methotrexate b/c of inflammation levels in my body. Whats your opinion on inflammation in the body & psoriasis?

Reduce inflammation. The more evidence of inflammation you have going on in your body, the more likely you are to have worsening symptoms of your psoriasis. Methotrexate helps to slow down the rate of DNA synthesis in epidermal cells which are what are proliferating too much of in your disease.More recent research shows it has immunosuppressive effects on activated T cells which contribute to inflammation of psoriasis. Read more...
Big question. Short answer: Inflammation is bad for you and increases all cause mortality (in other words increases risk of dying due to cancer, bones thinning, vascular disease, stoke, disabling arthritis, you get the idea.) Long answer is something you may want to read more about, but methotrexate is effective for treating inflammatory disease caused by the immune system attacking your own body. Take care. Read more...
MTX in psoriatic. arthritis is a proven treatment http://www.ncbi.nlm.nih.gov/pubmed/24566842 there is toxicity wtih it but it requires years to decades of MTX use. The newer antibody treatments are probably stronger and less toxic. Read more...

My age is 29yrs. For psoriasis, I'm taking methotrexate 7.5 mg since 7yrs. Using this, what are the side effects to me in long term. Plz suggest?

Probably not much. This is a small dose of methotrexate. Assuming you have blood tests to screen for medication toxicity and these tests are normal, the long term risk is small. Make sure blood is screened for liver toxicity and reduced blood counts every 3 months. Read more...

I was taking methotrexate a year for psoriasis & it helped a ton. When I stopped taking it my psoriasis went into overdrive & little spots all over?

Why did you stop. The first question is why did you stop. Methotrexate does not cure the psoriasis. It would help to discuss this with your physician. There are other alternatives including oral pill Otezla which is for psoriatic arthritis but soon will be indicated injections like Enbrel, (etanercept) Humira, etc also these are for Psoriatic Arthritis. and injections like stelera and Intravenous biologics like Remicad. Read more...
Why did you stop? MTX is a very good treatment for Psoriasis. If you had good response to it you should resume it. Please follow up with your Dermatologist for the same. Unless you had side effects, then there are other options. Read more...
Psoriasis. It sounds like the methotrexate was working for your psoriasis and since you have not been taking it, the psoriasis flares are worse. There are other treatments available for psoriaias that you should discuss with your doctor. Read more...
Psoriasis. Hi, see a Rheumatologist or Dermatologist for newer treatment options. Good luck. Read more...