Can you please explain the significance of monoclonal alpha chain without accompanying light chain?

Abnormal globulin. The gammaglobulins, which are proteins that defend our body from different diseases are formed of two chains the light and the heavy chain. In certain diseases, such as multiple myeloma, one cell starts to produce one type of (or part of) gammaglobulin. This proteins are all the same (therefore "monoclonal") and usually non-functioning. It can accumulate in tissues producing more damage.