Many genes. The previous answer is right with several genes associated with lupus, but no one knows how those genes cause disease. I think it's important to remember that there is likely many ways to develop lupus symptoms, and this will vary between people. So some of these known genes will be important for some, and not important for others. As we sequence more patients, we'll have more answers.
Numerous genes. There are multiple genes found as the cause of lupus. One is a mutation in the trex1 gene. Other genes include: blk, itgam, pxk, kiaa1542, rs10798269, and bank1 and there are more than a dozen of other known combination of genes.
Autoimmune. Systemic lupus erythematosus is an auto immune illness. This means people have a immume response against themselves and their own tissues. The hallmark blood test is a positive anti-nuclear antibody or an ana. Depending on what tissue is involved results in the clinical symptoms such as rash, arthritis, kidney disease etc. The cause seems be a combination of genetic and environmental exposures.
Drug-induced lupus. Yes, some prescription medications can definitely cause drug-induced lupus which often will resolve after the drug is stopped. Many of the drugs that can cause lupus do NOT cause lupus in the majority of people treated with them. There may be genetic susceptibility to drug-induced lupus and/or the right trigger. Many possible meds. Best way is to be evaluated by a board certified rheumatologist.
What to do if I have been dealing with active systemic lupus erythematosus. Can it be caused by prescription medication?
Yes. Certain meds can cause a drug-induced lupus. Google the subject and you will find the complete list.
Yes. A common symptom of sle is arthritis or joint pain and swelling which can involve just one hand. Usually there will be other symptoms as well such malar rash (red rash over the cheeks), increased sensitivity to sun, possibly hair loss and rash on the body, hands or knuckles or scalp.
With acute diffuse proliferative glomerulonephritis caused by systemic lupus erythematosus, why would a patient have uremia and hyperkalemia?
SLE DPGN is bad. The degree of remaining renal function dictates the inability of the kidney to excrete waste products and manage potassium levels. In any severe kidney disease when egfr approaches 15 ml/min uremia and elevated k+ levels are frequently noted.
Lupus nephritis. This disorder results in the immune system attacking the kidney filters, leading to loss of kidney function. If severe enough, it can lead to build up of toxins that are normally removed from the blood by the kidneys, a condition known as uremia. Excess potassium from our diet is removed by the kidneys as well, so with damaged kidneys, potassium levels can become too high, called hyperkalemia.
Yes, but. Theoretically, a "reboot" of the immune system, ie a bone marrow transplant, could cure lupus, but this is risky enough that it is very rare. The best treatment includes close monitoring with one's doctor and rheumatologist.
SLE treatment. Systemic lupus erythematosus (sle) is a long-term autoimmune disorder that may affect the skin, joints, kidneys, brain, and other organs. There is no cure for sle. The goal of treatment is to control symptoms.
Thin skin. Thin area around the nose/cheeks is very sensitive to sun and the first to show sle signs.
No. There are none other than using sunscreens.
Serious non-cancer. Lupus is a common multisystem autoimmune poorly-understood illness that is not cancer. It formerly killed many, if not most, of its victims. With today's treatments and a compliant, proactive patient, death is the exception. One of the most troublesome things is that lupus patients feel much sicker than they look, and this causes misunderstandings. Groups of fellow lupus-sufferers can help lots.
No, but. It is a serious illness that can shorten the life span of affected individual. Sle is an autoimmune disease and the body damages its own tissues and cells. It can result in multiple pathologies, including anemia, bleeding, arthritis, serositis, kidney disease etc. For more information please consult the website given below: http://www. Ncbi. Nlm. Nih. Gov/pubmedhealth/pmh0001471/.
Not a cancer. Sle is an autoimmune disease that can affects multiple organ including kidney, brain, joints, skin, blood, eyes etc. It is not cancer. Yes, it can be very debilitating and lethal if not treated properly. You need to see a rheumatologist and discuss in detail with your md.
Not a cancer. Sle is an autoimmune condition. The cause is unknown. While sle can be a serious and rarely fatal condition, the vast majority of patients do well with currently available medications and regular monitoring by a rheumatologist.