Can cause gi problem. Colchibe and indomethscin both can cause GI distress. Also problematic for patients with kidney disease.
No. It is not recommended that you take the 2 drugs together.
Yes. Work in different ways to address the problem.
Yes. I know of no drug-drug interaction between these 2 medications. You can always have a pharmacist check their computers. But the two medications listed work differently and hence there is no reason why they can't.