2 doctors weighed in:
Any one have a child with jra, stills disease?
2 doctors weighed in

Dr. Robert Lowe
Pediatric Rheumatology
In brief: Autoinflammatory dis
Systemic jia/jra is actually an autoinflammatory disease rather than an autoimmune disease and is more similar to periodic fever syndromes than RA or jra.
There's a problem with the innate immune system's triggering and control of inflammation, not a problem with mistakenly recognizing one's own proteins as foreign (like a virus). As such, Anakinra and steroids are most effective long term meds.

In brief: Autoinflammatory dis
Systemic jia/jra is actually an autoinflammatory disease rather than an autoimmune disease and is more similar to periodic fever syndromes than RA or jra.
There's a problem with the innate immune system's triggering and control of inflammation, not a problem with mistakenly recognizing one's own proteins as foreign (like a virus). As such, Anakinra and steroids are most effective long term meds.
Dr. Robert Lowe
Dr. Robert Lowe
Thank
Dr. Touraj Shafai
Pediatrics
In brief: Still's disease
Still's disease is the old name for sytemic onset jra, which starts with high fever and usually with no arthritis.
At times these childre have joint pain. They have high white blood cell and elevated sed. Rate. The DX in one of excluding a severe infection. Its association with hepatitis and dic was reported in ped, vol. 103. P 872, 1983. I am a co-author of this paper.

In brief: Still's disease
Still's disease is the old name for sytemic onset jra, which starts with high fever and usually with no arthritis.
At times these childre have joint pain. They have high white blood cell and elevated sed. Rate. The DX in one of excluding a severe infection. Its association with hepatitis and dic was reported in ped, vol. 103. P 872, 1983. I am a co-author of this paper.
Dr. Touraj Shafai
Dr. Touraj Shafai
Thank
1 comment
Dr. Robert Lowe
Kids will often have arthritis at the onset of systemic juvenile idiopathic arthritis (JIA) which can be quite severe. They can have low white blood cell counts, anemia and low platelets along with low (or falling) ESR which is a sign that macrophage activation syndrome is developing which is associated with elevated liver enzymes (hepatitis), and disseminated intravascular coagulation.
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