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Can you tell me what became of the investigational drug amn-107 for gist tumors?
2 doctors weighed in

In brief: Amn-107 is TASIGNA (nilotinib)
Amn 107 tasigna (nilotinib) is used for CML ( chronic myeloidleukemia ) especially if resistant to Gleevec fda did not aprove for gastointestinal stromal cell tumors ( gist ).

In brief: Amn-107 is TASIGNA (nilotinib)
Amn 107 tasigna (nilotinib) is used for CML ( chronic myeloidleukemia ) especially if resistant to Gleevec fda did not aprove for gastointestinal stromal cell tumors ( gist ).
Dr. Addagada Rao
Dr. Addagada Rao
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In brief: Complicated
A phase 1 trial has been completed and reported, but a phase 2 trial comparing amn107, or nilotinib, to imatinib (gleevec), was closed early due to interim analysis showing nonsuperiority.
It is being tried in combo with Gleevec in other trials. Fox chase has a trial. Nccn guidelines accept nilotinib as a treatment option but it's use is still off-label for now in gist.

In brief: Complicated
A phase 1 trial has been completed and reported, but a phase 2 trial comparing amn107, or nilotinib, to imatinib (gleevec), was closed early due to interim analysis showing nonsuperiority.
It is being tried in combo with Gleevec in other trials. Fox chase has a trial. Nccn guidelines accept nilotinib as a treatment option but it's use is still off-label for now in gist.
Dr. Debashish Bose
Dr. Debashish Bose
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