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Can you tell me the difference between peginterferon alfa 2a & peginterferon alfa 2b?

6 doctors weighed in
Dr. Jeffrey Crespin
Internal Medicine - Gastroenterology
4 doctors agree

In brief: Drug names

Both are pegylated interferons.
Peginterferon alfa 2a is made by roche branded Pegasys (peginterferon alfa 2a) and is a slightly larger molecule. Peginterferon 2B is made by schering and its dose is calculated based on body weight. The brand name is peg-intron. These drugs have similar efficacy and side effects.

In brief: Drug names

Both are pegylated interferons.
Peginterferon alfa 2a is made by roche branded Pegasys (peginterferon alfa 2a) and is a slightly larger molecule. Peginterferon 2B is made by schering and its dose is calculated based on body weight. The brand name is peg-intron. These drugs have similar efficacy and side effects.
Dr. Jeffrey Crespin
Dr. Jeffrey Crespin
Thank
Dr. Hashmat Rajput
Internal Medicine

In brief: Interferons

These are 2 different interferon molecules attached to peg.
(polyethylene glycol). Alpha2a attached with lysine and Alpha 2b with histidine. Alpha 2has longer half life ; given weekly with no body wt consideration. Alpha 2b is short lived ; weight dependent dosage. Thanks.

In brief: Interferons

These are 2 different interferon molecules attached to peg.
(polyethylene glycol). Alpha2a attached with lysine and Alpha 2b with histidine. Alpha 2has longer half life ; given weekly with no body wt consideration. Alpha 2b is short lived ; weight dependent dosage. Thanks.
Dr. Hashmat Rajput
Dr. Hashmat Rajput
Thank
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