Does taking tamoxifen for breast cancer treatment induce cancer of the womb?

Small risk. Tamoxifen is asociated with a small (less than 5%) risk of uterine cancers, women on tamoxifen require regular gynecologic checkups every 6-12 months and high-risk women may need ultrasound screeenings too.
Possible but rare. Uterine wall thickening is a known side effect of tam. It usually presents as abnormal spotting or bleeding. Definitive DX is via endometrial biopsy. If ignored it can progress to uterine cancer. This is usually cured with hysterectomy alone.

Related Questions

Can taking tamoxifen for breast cancer treatment induce cancer of the uterus?

Maybe. There is a slight increased risk of endometrial cancer of 1 in 500 chance reported. The benefits of tamoxifen in treatment of breast cancer is much higher than the risk of endometrial cancer. Ask your oncologist and ob-gyn how best to follow or watch for this potential risk. Read more...

Does taking tamoxifen for breast cancer treatment induce development of cancer of the uterus?

It can. Studies show that women who take tamoxifen have twice the risk of uterine cancer as compared to non treated patients. However, the benefits of tamoxifen for the treatment of breast cancer far outweigh the risks. Aromatase inhibitors are a group of drugs that can be used instead of tamoxifen for post-menopausal breast cancer patients; these drugs do not have this risk. Read more...
Yes. The chance is about 1% and treatment is hysterectomy. With such a low chance then tamoxifen is worth the risk. A gynecologist needs to keep track of the patient and any unusual bleeding evaluated. There are also other hormone alternatives with less risk. Check with your medical oncologist to see which drug is best for a particular patient. Read more...

Does taking tamoxifen for breast cancer treatment cause cancer of the uterus?

Yes. Tamoxifen has been shown to increase the risk of uterine cancer, not unlike estrogen replacement therapy, with an incidence of ~1:500. However, this is almost-always caught at its earliest stage, with very high cure rates. If you compare the benefit of tamoxifen for either treating or preventing breast cancer compared to this risk, the benefit far outweighs the risk. Read more...
Tamoxifen. If you get vaginal bleeding, you need a biopsy of the endometrium. Some doctors do ultrasounds looking for polips as well . Read more...

When is tamoxifen for breast cancer treatment?

See below. Tamoxifen can be used after other treaments such as surgery, radiation and chemotherapy to prevent a cancer recurrence, or it can be used if cancer has spread in order to slow it's growth. Read more...
Chemotherapy. Tamoxifen is a very effective drug for the treatment of hormone-sensitive (estrogen receptor +) breast cancers. It may be used alone or in combination with traditional IV chemotherapy, depending on the cancer stage. Furthermore, tamoxifen has been shown to be effective reducing the chance of developing breast cancer in high-risk women ("chemoprevention"). Read more...

Is tamoxifen a must for er/pr negative menstruating woman for breast cancer treatment?

No. Actually, it's er/pr positive women who are potential candidates for tamoxifen. This is advised for women whose cancer stage mandates chemotherapy, sometimes combined with traditional IV chemotherapy. Furthermore, we often recommend tamoxifen to prevent the development of a second cancer is breast cancer survivors. Read more...
No. This and similar medicines are anti Estrogens that block the receptors. So if the patient has negative receptors there is little benefit from the medication. So it's not a must. Read more...

Is it okay for an oncologist to do breast cancer treatment without tamoxifen?

Yes. Tamoxifen is a very effective drug for the treatment of hormone-sensitive (estrogen receptor +) breast cancers. It may be used alone or in combination with traditional IV chemotherapy, depending on the cancer stage. It has no role in rx of estrogen (-) breast ca. Furthermore, aromatase inhibitors are an effective alternative to tamoxifen for estrogen (+) breast cancer after menopause. Read more...
Yes! Tamoxifen is only useful in breast cancers which are estrogen receptor positive(er+). So tamoxifen is of no use if the tumor is er negative. Check your tumor's hormone receptor status and you will have the answer to your question>. Read more...

How has breast cancer treatment improved over time?

Many ways. In many ways it has improved. First of all withearlier detection there is less need of less aggressive excisions and chemo and radiotherapy. Have many advances in chemotherapy, for example it is a lot more targeted to specific receptors on the cancer. Read more...
Yes, remarkable. Progress is achieved in recent years , but still long way to reach the goal the cure , due to awareness , early diagnosis , improved diagnostic tools , ( better mammography , MRI , etc ) , improved knowledge in biology of tumor , genetics , availability and advances in chemotherapy and more and financial contribution for research by people like you. Read more...

Is there a less toxic alternative to chemotherapy for breast cancer treatment?

Yes. We look at each cancer's profile - estrogen / Progesterone /her-2 receptors as well as histology-size, grade , blood vessel invasioneg then the patient herself age menopause status-if recepto pos. And older pt. Ie postmenopausal we often treat with hormonal therapy - pills - that have a less severe side effect profile but still not without problems - osteoporosis uterine cancer catarats. Read more...
Hormonal Therapy. The vast majority (80-85%) of breast cancer is hormone sensitive/driven. Pathology testing can determine if a tumor is er+. Unless otherwise contraindicated, all er+ patients should be considered for hormone therapy. If strongly er+, they may get more benefit from this than from chemotherapy. Specialized testing (oncotype dx) is often used to determine if chemotherapy is still needed in er+ pt. Read more...
Potentially. Brca tx may include chemo, hormones, radiation, bone targeted tx & diet/exercise as "adjvuant" (post surgery) treatment. The combo needed depends on the tumor characteristics (grade, stage, hormone receptor status - er, pr; and her2/neu status). Non chemo tx can include hormones - eg tamoxifen, arimidex, (anastrozole) etc; trastuzumab (herceptin - anti her2 antibody). Optimal therapy may include all those. Read more...
Yes. In some cases hormonal treatment can be as effective as chemotherapy. However if there is benefit from chemotherapy then it would be in addition to hormonal therapy. You should ask what percent benefit chemotherapy would give your circumstance and then decide if it's worth it to you to not accept that benefit. Read more...

Are there negative effects of breast cancer treatment/ mammography after a year? What should I expect?

Mammo is low risk. Treatment effects can vary significantly depending on what is done (type of surgery, radiation, chemo). Mammography should not have any significant effects, especially after one year. Mammograms are low dose radiation, but any radiation can increase cancer risk over the long term (decades). The cancer risk from mammograms is extremely low. Note that you are below the recommended screening age. Read more...