Reversible. Since it is due to igg antibodies that come across the placenta, these eventually disappear after about six months. This some of the symptoms such as rash and low platelets can resolve. Heart block is more of a permanent problem and will need long-term treatment and sometimes a permanent pacemaker for the child.
Transient-permanent. Some of the transient problems can reverse but are still serious. The rash can resolve, low platelets can improve but the heartblock can be permanent.
Yes. Neonatal lupus depends on antibodies transfered across the placenta to the baby. Sometimes the mother has the antibodies but does not have clinical disease. The antibodies cross the placenta and cause the lupus in the baby even if the mother never had identified disease. The clinical picture can include rash, heart block, low platelets. The heart occur before delivery and may need a pacemaker.
Baby Lupus. Neonatal lupus erythematosus presents in infants, most often girls, born to mothers who carry the ro/ssa antibody. Neonatal lupus can cause a decrease in red cells (anemia), white blood cells and platelets, and a skin rash. Problems can also develop in the electrical system of the baby's heart (congenital heart block). A pacemaker for the baby's heart may be needed in this setting.
Autoimmune disease. Neonatal lupus is a passively transferred autoimmune disease. It occurs in ~1-2% of babies born to mothers with autoimmune disease, primarily systemic lupus erythematosus and sjögren’s syndrome, and antibodies to ssa/ro and/or ssb/la. Many cases occur in children of mothers who have the same autoantibodies, but who do not have symptoms of lupus or other autoimmune diseases.
Not usually. It will most often resolve on its own.
Spectrum, but. Spectrum of lupus damage, but heart block esp to be considered.
It depends. Some mothers can have babies with neonatal lupus but the mohters were never aware that they had lupus because they did not have clinical lupus. What they had were the antibodies of people with lupus and even without clincial symtoms of lupus they still had lupus - like an iceberg the symptoms in this case the antibodies that cause neonatal lupus were below the water.
Probably not! Infantile. Sle is extrely rare in infants. Starts more commonly in pubertal females. Anas are commonly transferred but this not last. There significant autoimmune problems, but sle is not one.
Yes. Neonatal lupus depends on antibodies transfered across the placenta to the baby. Sometimes the mother has the antibodies but does not have clinical disease. The antibodies cross the placenta and cause the lupus in the baby even if the mother never had identified disease.