Why do they treat some woman with breast cancer with herceptin (trastuzumab)?

Herceptin (trastuzumab) breast ca. About 1/4 cases of breast cancer express a protein on the surface of the cancer cells called her2neu which is a member of the epidermal growth factor family of receptors important for growth signaling into the cell nucleus. Herceptin (trastuzumab) is an antibody developed to target her2neu and antagonize this growth signaling and kill the cancer cell. Chemo is synergistic with Herceptin (trastuzumab) when given together.
Some have her-2-neu. Expressed; some do not. It only works on those who express sufficient her-2-neu copies by fish (fluoroescent in-sit hybrization), a test done on the cancer tissue at the pathology lab.

Related Questions

Is herceptin (trastuzumab) just can heal breast cancer?

Herceptin (trastuzumab) Herceptin (trastuzumab) is approved for the treatment of early-stage breast cancer that is human epidermal growth factor receptor 2-positive (her2+) and has spread into the lymph nodes, or is her2+ and has not spread into the lymph nodes. If it has not spread into the lymph nodes, the cancer needs to be estrogen receptor/progesterone receptor (er/pr)-negative or have one high risk feature. Read more...
Will help. Certain types of cancers called her 2 + cancers in those cancers her protein stimulates cancers cells , trastuzumab ( Herceptin ) a monoclonal antibody interferes at receptor site , cancer cell multiplication ( in way you can call it ' heal breast cancer ' in layman terms ) . Read more...

What do I need to know about herceptin (trastuzumab) after breast cancer?

Herceptin (trastuzumab) Herceptin (trastuzumab) is a targetted therapy that inhibits her2-neu receptor . Herceptin (trastuzumab) has been given to patient with her2neu receptor positive breast cancer with improvement of response and survival. Herceptin (trastuzumab) has been also one of treatment options for her2 reeptor positive stomach cancer. Read. Mire about Herceptin (trastuzumab) at www.Cancer.Net, www.Cancer.Org, www.Nccn.Com. Read more...

Does being on herceptin (trastuzumab) for breast cancer cause you to gain weight?

Haven't seen that. Unlike some of the hormonal therapies, Herceptin (trastuzumab) should not cause weight gain except of course if the person is debilitated and the drug improves your condition...Then i would actually expect healthy weight gain. That I have seen. Read more...
No. Herceptin (trastuzumab) should not by itself cause weight gain. But some women do gain weight when they are taking chemotherapy or soon after they have completed their course of chemotherapy. Caution is advised in terms of eating mindfully eating in moderation and eat healthful foods(low in fat content). Read more...
No. Herceptin (trastuzumab) is not associated with weight gain. However sometimes weight gain can happen during or following chemotherapy due to the use of steroids prior to chemotherapy. However not related to Herceptin (trastuzumab) use. Read more...

Stage 3 breast cancer her2 positive how many herceptin (trastuzumab) cycle she must undergo?

Up to 1 year's worth. Herceptin (trastuzumab) can be given together with initial chemotherapy for the first 4-6 months then subsequently by itself for a total of 1 year. If chemotherapy was given first without Herceptin (trastuzumab) then Herceptin (trastuzumab) can be given for a full year by itself. The usual cycle runs every 3 weeks (17-18 cycles in one full year). Read more...
1 year. The standard of care for stage 1, 2, 3 breast cancer is a year of herceptin (trastuzumab). It is probably the most important drug in her 2 positive breast cancer! Read more...

Is there any oral maintenance medicine fot her2 breast cancer after finishing the herceptin (trastuzumab)?

Yes. First very close follow up by the oncologist, preventing osteoporosis, zometa will help ske ( skeletal related events , like fractures joint and muscle problems ) in 40% , risk of metastasis in 14 % , speak to your oncologist. Read more...
Hormonal treatment. If the cancer is er positive then tamoxifen or an aromatase inhibitor would be beneficial to reduce the risk of recurrence. Read more...

What are financial implications of using herceptin (trastuzumab) as a breast cancer treatment?

? I have never had an issue of trastuzumab (herceptin) coverage in appropriate patients. Individual co-pays are based on each patients insurance. There may be a benefit of trastuzumab in 0/low expression breast cancer that is the subject of a cooperative group clinical trial -- nsabp b-47 - clinicaltrials.Gov id: nct01275677. Read more...
Depends . Herceptin (trastuzumab) is a very expensive drug so the total cost of treatment will be obviously higher. That said, it is a good drug and most insurances will cover its use in the appropriate setting. Best regards. Read more...
Good question. Herceptin (trastuzumab) is very effective for breast cancers that overexpress the her2/neu receptor. But as you point out it is very expensive. The financial implications are huge for the us healthcare system. Studies done outside the us show that far less than 1 year of Herceptin (trastuzumab) may be enough for treating early stage breast cancer, but studies done in the us don't look at how to make treatments less costly. Read more...