10 doctors weighed in:

Does tamoxifen help prevent breast cancer?

10 doctors weighed in
Dr. Chad Levitt
Radiation Oncology
4 doctors agree

In brief: And new primaries

Tamoxifen blocks estrogen and Progesterone receptors which when stimulated can cause remnant cancer cells to be stimulated to grow back and also can cause normal cells to be overstimulated to develop into new hormonally sensitive cancer. Statistically it reduces the chance of recurrence by 30% and reduces the chance of a second primary by 50%.

In brief: And new primaries

Tamoxifen blocks estrogen and Progesterone receptors which when stimulated can cause remnant cancer cells to be stimulated to grow back and also can cause normal cells to be overstimulated to develop into new hormonally sensitive cancer. Statistically it reduces the chance of recurrence by 30% and reduces the chance of a second primary by 50%.
Dr. Chad Levitt
Dr. Chad Levitt
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Dr. Sean Canale
Breast Surgery
4 doctors agree

In brief: Yes - ER+ breast CA

The p-1 trial showed in high risk women tamoxifen decreased the risk of er+ tumors by 40-50% (no difference in er- tumors) over palcebo.
The p-2 or star trial compared tamoxifen to raloxifene/evista and saw similar overall benefits with some slight variations. Recently, a new trial has shown 65% reduction benefit for the aromatase inhibitor Exemestane over placebo.

In brief: Yes - ER+ breast CA

The p-1 trial showed in high risk women tamoxifen decreased the risk of er+ tumors by 40-50% (no difference in er- tumors) over palcebo.
The p-2 or star trial compared tamoxifen to raloxifene/evista and saw similar overall benefits with some slight variations. Recently, a new trial has shown 65% reduction benefit for the aromatase inhibitor Exemestane over placebo.
Dr. Sean Canale
Dr. Sean Canale
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Dr. Sabha Ganai
Surgery - Oncology
2 doctors agree

In brief: Secondary Prevention

Tamoxifen also can be used to prevent breast cancer in the other breast as well as "secondary prevention" of breast cancer in patients who are at higher than normal risk of developing breast cancer.

In brief: Secondary Prevention

Tamoxifen also can be used to prevent breast cancer in the other breast as well as "secondary prevention" of breast cancer in patients who are at higher than normal risk of developing breast cancer.
Dr. Sabha Ganai
Dr. Sabha Ganai
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Dr. Travis Kidner
Surgery - Oncology
2 doctors agree

In brief: Recurrence

It prevents recurrence in women with estrogen receptor positive tumors.

In brief: Recurrence

It prevents recurrence in women with estrogen receptor positive tumors.
Dr. Travis Kidner
Dr. Travis Kidner
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1 comment
Dr. Sabha Ganai
Tamoxifen also can be used to prevent breast cancer in the other breast as well as "secondary prevention" of breast cancer in patients who are at higher than normal risk of developing breast cancer.
Dr. Barry Rosen
Surgery
1 doctor agrees

In brief: Yes.

Tamoxifen use may reduce the development of breast cancer in high-risk patients by about 50%.
There are risks associated with tamoxifen, so the decision whether to take this medication is based upon an individual patient's risk:benefit analysis.

In brief: Yes.

Tamoxifen use may reduce the development of breast cancer in high-risk patients by about 50%.
There are risks associated with tamoxifen, so the decision whether to take this medication is based upon an individual patient's risk:benefit analysis.
Dr. Barry Rosen
Dr. Barry Rosen
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