Are there any other alternatives to tamoxifen for breast cancer?

Additional info. Also let me add additional alternatives if pre-menopausal 1) bilateral oophorectomy (surgical or radiation) 2) chemical oophorectomy (goserelin or gnrh agonist). If this were chosen your oncologist might recommend aromatase inhibitor therapy, although this is a controversial topic.
Sometimes. If you are taking tamoxifen for treatment of breast cancer and are post-menopausal, a class of drugs called aromatase inhibitors may be even more effective. If tamoxifen is being used for cancer prevention, Raloxifene (evista) is an effective alternative.
Aromatase inhibitor. Tamoxifen is used for women who are premenopausal and have an estrogen responsive tumor. Aromatase inhibitors are used for the same tumors in women who are in menopause.

Related Questions

When is tamoxifen for breast cancer treatment?

See below. Tamoxifen can be used after other treaments such as surgery, radiation and chemotherapy to prevent a cancer recurrence, or it can be used if cancer has spread in order to slow it's growth. Read more...
Chemotherapy. Tamoxifen is a very effective drug for the treatment of hormone-sensitive (estrogen receptor +) breast cancers. It may be used alone or in combination with traditional IV chemotherapy, depending on the cancer stage. Furthermore, tamoxifen has been shown to be effective reducing the chance of developing breast cancer in high-risk women ("chemoprevention"). Read more...

Does tamoxifen for breast cancer put me at risk for uterine cancer?

Yes. Studies have shown that women taking tamoxifen have twice the risk of developing uterine cancer as compared to the general population. However, the benefits of tamoxifen far outweigh this risk when treating many breast cancers. When taking tamoxifen, it is critical to see your gynecologist yearly and be mindful of any pelvic pain or irregular menstrual bleeding. Read more...
Yes. like ERT. The increase risk is similar to that of unopposed estrogen replacement therapy. It is important that all your doctors (esp your gyn in this case) are aware what medications you're taking and report any irregular vaginal bleeding/discharge or other pelvic symptoms. Read more...

How effective is taking low-dose tamoxifen for breast cancer risk reduction?

Only One Dose. The use of tamoxifen for chemoprevention is associated with a 50% reduction in breast cancer in those at high risk. Like any drug, there are side-effects and potential complications. Therefore, this decision is best made in consultation with a cancer specialist. Read more...

Can the intake of tamoxifen for breast cancer affect our uterus?

Yes. Tamoxifen can stimulate the utermine lining, can cause abnormal menstrual type bleeding, and could be a risk factor for uternine cancer. The benefits far outweight the risks, though.Tamoxifen can also increase the risk of blood clots, but lowers osteoporosis risk. Read more...
Yes, it does. Yes! tamoxifen is a quirky drug! it binds to the estrogen receptor on cells, and in most places blocks the activity of estrogen. But in some places, including the uterus, tamoxifen turns on the receptor instead of turning it off. This causes the lining of the uterus to build up and get thick. This slightly increases the risk of uterine cancer, especially in older women. Read more...

What to do if I do not have monthly period for about 2 years and 9 moths because of chemotherapy and because of taking tamoxifen for breast cancer.?

May not be a problem. Chemotherapy in women as young as you, and also tamoxifen, may stop periods (usually temporarily at your age). You should not assume you cannot get pregnant, barrier contraception is still recommended (if you follow contraceptive practices - tamoxifen during pregnancy is not recommended). If it is causing menopausal symptoms, discuss them with your prescribing physician as there are options. Read more...

Does taking tamoxifen for breast cancer treatment induce cancer of the womb?

Small risk. Tamoxifen is asociated with a small (less than 5%) risk of uterine cancers, women on tamoxifen require regular gynecologic checkups every 6-12 months and high-risk women may need ultrasound screeenings too. Read more...
Possible but rare. Uterine wall thickening is a known side effect of tam. It usually presents as abnormal spotting or bleeding. Definitive DX is via endometrial biopsy. If ignored it can progress to uterine cancer. This is usually cured with hysterectomy alone. Read more...

Does taking tamoxifen for breast cancer treatment cause cancer of the uterus?

Yes. Tamoxifen has been shown to increase the risk of uterine cancer, not unlike estrogen replacement therapy, with an incidence of ~1:500. However, this is almost-always caught at its earliest stage, with very high cure rates. If you compare the benefit of tamoxifen for either treating or preventing breast cancer compared to this risk, the benefit far outweighs the risk. Read more...
Tamoxifen. If you get vaginal bleeding, you need a biopsy of the endometrium. Some doctors do ultrasounds looking for polips as well . Read more...

Can taking tamoxifen for breast cancer treatment induce cancer of the uterus?

Maybe. There is a slight increased risk of endometrial cancer of 1 in 500 chance reported. The benefits of tamoxifen in treatment of breast cancer is much higher than the risk of endometrial cancer. Ask your oncologist and ob-gyn how best to follow or watch for this potential risk. Read more...