Why does hydralazine work in treating congestive heart failure in african americans?

Unloads the heart. Hydralazine dilates the blood vessels, lowers the blood pressure and unloads the heart. This along with nitrates is particularly helpful if unable to take or have insufficient BP lowering from ace inhibitors/ arb.

Related Questions

How does isosorbide dinitrate and hydralazine work in treating congestive heart failure?

A-HEFT Trial. A large trial looked at the combination of hydralazien and Isordil (isosorbide dinitrate) with african american patients and showed a benefit of improving heart failure status, on top of standard medical therapy. It is thought to be believed due to lack of Nitric Oxide delivery to endothelium in african americans, that is improved by this therapy. Blood pressure tends to be higher in the first place, which improves. Read more...