7 doctors weighed in:
Do ADHD medications target norepinephrine?
7 doctors weighed in

Dr. R Sangal
Internal Medicine - Sleep Medicine
5 doctors agree
In brief: Depends on the med
It depends on the medicine.
Amphetamines and methylphenidate work predominantly on dopamine, but also on norepinephrine. Atomoxetine works selectively on norepinephrine, as does guanfacine. Off-label medicines such as Imipramine and bupropion have effects on several brain chemicals (imipramine may work on norepinephrine, acetylcholine, histamine).

In brief: Depends on the med
It depends on the medicine.
Amphetamines and methylphenidate work predominantly on dopamine, but also on norepinephrine. Atomoxetine works selectively on norepinephrine, as does guanfacine. Off-label medicines such as Imipramine and bupropion have effects on several brain chemicals (imipramine may work on norepinephrine, acetylcholine, histamine).
Dr. R Sangal
Dr. R Sangal
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Dr. Alfredo Soto
Psychiatry
1 doctor agrees
In brief: Yes
Most, if not all, medications shown to help adhd have been associated with effects on norepinephrine.
Many also target Dopamine receptors.

In brief: Yes
Most, if not all, medications shown to help adhd have been associated with effects on norepinephrine.
Many also target Dopamine receptors.
Dr. Alfredo Soto
Dr. Alfredo Soto
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Dr. Carla Enriquez
Pediatrics
In brief: Yes
Norepinephrine (ne) is produced by brain cells to send through a connection called a "synapse" to contact another brain cell with its information bits.
Adhd meds target increased production in the sending cell, or blockage of breakdown at the receiving cell. By so doing, the normal cell information lasts longer to allow for better connectivity between neurons.

In brief: Yes
Norepinephrine (ne) is produced by brain cells to send through a connection called a "synapse" to contact another brain cell with its information bits.
Adhd meds target increased production in the sending cell, or blockage of breakdown at the receiving cell. By so doing, the normal cell information lasts longer to allow for better connectivity between neurons.
Dr. Carla Enriquez
Dr. Carla Enriquez
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