Probably nothing. Depends on why this is being done.
Don't take together. These drugs do not go together. Nolvadex or tamoxifen is an antagonist to estrogen. It is usually given in the setting of estrogen sensitive breast cancer. So giving a synthetic form of estrogen like Premarin (conjugated estrogens) goes counter to that treatment.
Not recommended. Premarin (conjugated estrogens) is a hormone replacement used after menopause. Nolvadex/tamoxifen is used to treat estrogen responsive breast cancers. Premarin (conjugated estrogens) adds estrogen while tamoxifen blocks estrogen from being used by tumor cells. Not a good combination. If you are experiencing menopausal symptoms (hot flash, vaginal dryness, etc), there are other medications that can help. Speak with your oncology team.
Not a good idea. The two drugs are opposite. Premarin (conjugated estrogens) is a synthetic estrogen and Nolvadex (tamoxifen) is a drug that blocks the estrogen receptor. So basically, the two cancel each other - you might experience side effects but have virually no benefit.
Very standard. Dose.
No, but... Your better option is Estradiol alone. Also 90 day supply $10 at many places, ie. Walmart and cosco! But the real reason is this! Premarin (conjugated estrogens) contains much more estrone than estradiol. Estradiol is the dominant hormone in non-pregnant females, while estrone is dominant only during pregnancy. There is strong evidence that Estradiol is better for females than the hormone estrone!
Premarin (conjugated estrogens) It is a female hormone medication containing estrogen.
Premarin (conjugated estrogens) Premarin (conjugated estrogens) is the trade name for a hormone replacement product conjugated equine estrogen. It is a combination of approximately 17 forms of estrogen and used to treat menopausal symptoms such as hot flashes and vaginal dryness. This medication has been extensively studied as part of the women's health initiative (whi).
Positive. Lack of estrogen causes thin lax skin and delayed healing', replacement helps prevent these things as much as possible. It's a good thing!
Weight gain etc. Most of my patients on Premarin (conjugated estrogens) do quite well as the benefits of taking it far out weigh the risks. Weight gain, bloating, breast, uterus cancer, blood clot, ht attack, stoke. These are all very uncommon in a healthy person taking this medication. If you have a uterus you will need to take Progesterone also but if you don't then u can just take estrogen which is safer.
Conjugated estrogens. The Conjugated Estrogens are off patent are generally available by generic form and thus tend to be less exprensive that bio-identical forms that are not regulate.