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How does a procainamide challenge?

2 doctors weighed in
Dr. Ryan Keller
Anesthesiology
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In brief: Reveals Arrhythmia

Procainamide is a local anesthetic that acts on sodium channels.
In the heart muscle sodium channels play a central role in the excitability of myocardial cells. So if you are given a bolus of this drug, it has the ability to increase the detection rate of an arrhythmia without losing predictive value. Meaning if it can produce an arrhythmia you may have a condition that needs to be treated.

In brief: Reveals Arrhythmia

Procainamide is a local anesthetic that acts on sodium channels.
In the heart muscle sodium channels play a central role in the excitability of myocardial cells. So if you are given a bolus of this drug, it has the ability to increase the detection rate of an arrhythmia without losing predictive value. Meaning if it can produce an arrhythmia you may have a condition that needs to be treated.
Dr. Ryan Keller
Dr. Ryan Keller
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