Leptin resistance. Studies are finding, however, that the majority of overweight individuals that are having difficulty losing weight have varying degrees of leptin resistance. The leptin is unable to produce its normal effects of weight loss, with the severity correlating with the degree of obesity.
Leptin and weight. There are two major gut hormones involved in weight control. Ghrelin and leptin. They are opposites. High ghrelin levels make you hungry, and high leptin levels make you feel full. That is a very broad generalization but you get the idea. If one is high, the other is usually low. And abnormality of either hormone could theoretically lead to weight gain.
Leptin is made by fa. Leptin is made by fat cells in response to meals and calorie availability. When energy is present in abundant amounts, fat cells tell your body to consume fewer calories. Obese patients can be "leptin resistant" with high levels of circulating leptin without it having a strong inhibitory effect. Read more...