What are the effects of prolonged hydrocodone use on your liver?

It's the tylenol (acetaminophen) Hydrocodone is usually dispensed in pills that also include tylenol (or acetaminophen). It's the tylenol component that is damaging to the liver. An otherwise healthy person should consume less than 3, 000-4, 000 milligrams of tylenol in a given 24 hour period. If you have liver disease, you should avoid tylenol products. Oxycodone is a comparable narcotic that is available without tylenol.