3 doctors weighed in:

Why do patients taking gnrh-a lose bone?

3 doctors weighed in
Dr. Giuseppe Barbesino
Internal Medicine - Endocrinology
1 doctor agrees

In brief: GnRH hormones

While normally gnrh stimulates sex hormones, it achieves this only when it is secreted in bursts by the hypothalamus.
When given in injections, it circulates continuously and it suppresses the hormones that in turn stimulate the ovary in women and the testes in men. As a consequence, there is a lack of sex hormones (estradiol in women, testosterone in men, leading to bone loss as in menopause.

In brief: GnRH hormones

While normally gnrh stimulates sex hormones, it achieves this only when it is secreted in bursts by the hypothalamus.
When given in injections, it circulates continuously and it suppresses the hormones that in turn stimulate the ovary in women and the testes in men. As a consequence, there is a lack of sex hormones (estradiol in women, testosterone in men, leading to bone loss as in menopause.
Dr. Giuseppe Barbesino
Dr. Giuseppe Barbesino
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Dr. Michael Traub
Fertility Medicine

In brief: Shuts down brain

Gnrh ends up shutting down your brains production of hormones.
The pituitary then does not make lh and fsh and your ovary does not make estrogen. And the lack of estrogen affects your bone.

In brief: Shuts down brain

Gnrh ends up shutting down your brains production of hormones.
The pituitary then does not make lh and fsh and your ovary does not make estrogen. And the lack of estrogen affects your bone.
Dr. Michael Traub
Dr. Michael Traub
Thank
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