6 doctors weighed in:

What is the difference between tamoxifen and femara (letrozole)?

6 doctors weighed in
Dr. Quang Nguyen
Internal Medicine - Endocrinology
4 doctors agree

In brief: Different

Tamoxifen is a selective estrogen agonist/antagonist.
It binds to estrogen receptors and depends on which organ it's on, it either exerts anti-estrogen or estrogen effects. Femara (letrozole) is an aromatase inhibitor. It inhibits enzymatic conversion of androgens to estrogen thereby lowering estrogen level.

In brief: Different

Tamoxifen is a selective estrogen agonist/antagonist.
It binds to estrogen receptors and depends on which organ it's on, it either exerts anti-estrogen or estrogen effects. Femara (letrozole) is an aromatase inhibitor. It inhibits enzymatic conversion of androgens to estrogen thereby lowering estrogen level.
Dr. Quang Nguyen
Dr. Quang Nguyen
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Dr. Eric Brown
Breast Surgery

In brief: Mechanism of action

The two drugs are similar. However, the way they work (mechanism of action) is different.
They are used to treat hormone sensitive cancers and (tamoxifen) high risk patients. If you are premenopausal, because of the different mechanisms of action, you should not take femara (letrozole).

In brief: Mechanism of action

The two drugs are similar. However, the way they work (mechanism of action) is different.
They are used to treat hormone sensitive cancers and (tamoxifen) high risk patients. If you are premenopausal, because of the different mechanisms of action, you should not take femara (letrozole).
Dr. Eric Brown
Dr. Eric Brown
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