What is the difference between the direct Coombs test and indirect Coombs test?

Bound vs unbound ABs. Direct coombs' test is used to detect antibodies that are already bound to the surface of red blood cells. Many diseases and drugs (quinidine, methyldopa, and procainamide) can lead to production of these antibodies indirect coombs' test looks for unbound circulating antibodies against a series of standardized red blood cells. The indirect coombs' test is only rarely used to diagnose a condition.

Related Questions

What are the differences between direct Coombs test and indirect Coombs test?

Both test Ag-Ab rxns. Direct Coombs will test for the reaction using the patient’s RBCs, if there is a reaction, then the direct test is positive, used to test for autoimmune hemolytic anemia. Indirect Coombs test uses the patient’s serum (not rbcs) which is added to rbcs that are known to have a certain antigenicity, positive in cases of hemolytic diseases of the newborn, mother's serum against baby's RBCs, Read more...

S there difference between indirect and direct Coombs test?

Yes. The direct coombs test is typically used to test for autoimmune hemolytic anemia, a disorder involving destruction of red blood cells. It determines whether or not antibodies are present on the surface of the patient's rbcs. The indirect coombs test is typically used to test for blood type compatibility prior to a transfusion, and detects the presence of antibodies in the serum of the patient. Read more...

What is the indirect and direct Coombs test?

RBC antibodies. These tests are used to detect antibodies against red blood cells (rbcs). The direct coombs test is used in autoimmune hemolytic anemia. That's when your antibodies attack & destroy you own rbcs. The indirect test is used to detect potential transfusion reactions & in pregnancy especially for rh incompatibility when mom is rh- & fetus is rh+. For a more complete explanation see wikipedia. Read more...

I am rh- and my boy friend is rh- so will my babys indirect Coombs test came back positive?

Baby is also Rh- . Your baby will also be rh-. Because rh- is recessive to rh+ you and your boyfriend both have two rh- genes. Your haplotype is rh-/rh- and your phenotype rh- and so is his. You and he can only give rh- genes to your babies. All of your babies with this father will be rh-/rh-. Don't sweat it. Read more...

Is the direct Coombs test done at birth testing the baby or the mother? Whose Coombs is being tested?

Baby's Red cells and. mother's antibodies. The Direct Coombs test in a newborn is done to look for maternal antibodies that may have coated the baby's red cells. So, in a way both are being tested, but it is mainly to test for maternal antibody induced hemolytic anemia in the baby. Read more...