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What is the indirect and direct Coombs test?
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Dr. Steven Machtinger
Internal Medicine - Allergy & Immunology
In brief: RBC antibodies
These tests are used to detect antibodies against red blood cells (rbcs).
The direct coombs test is used in autoimmune hemolytic anemia. That's when your antibodies attack & destroy you own rbcs. The indirect test is used to detect potential transfusion reactions & in pregnancy especially for rh incompatibility when mom is rh- & fetus is rh+. For a more complete explanation see wikipedia.

In brief: RBC antibodies
These tests are used to detect antibodies against red blood cells (rbcs).
The direct coombs test is used in autoimmune hemolytic anemia. That's when your antibodies attack & destroy you own rbcs. The indirect test is used to detect potential transfusion reactions & in pregnancy especially for rh incompatibility when mom is rh- & fetus is rh+. For a more complete explanation see wikipedia.
Dr. Steven Machtinger
Dr. Steven Machtinger
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